Semaglutide improves life quality of HFpEF patients with obesity - a phase III study (STEP-HFpEF)
Heart failure with preserved ejection fraction (HFpEF) comprises about 50% of heart failure cases, affecting at least 64 million people worldwide. Obesity is a major driver for HFpEF; obese patients have severe symptoms such as increased inflammation, reduced exercise capacity, and exertion, degrading life quality. Current medications are not effective in treating HFpEF in obese patients. There is a need for a new drug to improve their quality of life. Earlier studies have demonstrated that weight loss improves HFpEF symptoms. We aim to determine the effect of the weight loss drug- semaglutide - a GLP-1R agonist in treating HFpEF in obese patients.
